Seminar "How to do without high-field magnets?"

Hello,

You are cordially invited to the seminar on Friday, June 4, 2021 at 10:30 a.m. entitled :

How doing without high field NMR magnets? Compact NMR and advanced methods: From single molecule to complex intracellular mixtures

How doing without high field magnets? Compact NMR and advanced methods: From single molecule to complex intracellular mixtures

moderated by Dr Jonathan FARJON

CEISAM, EBSI team, Nantes Faculty of Science and Technology,

which will take place by videoconference, given the current context (see links and information below).

Abstract:

The sensitivity of high-field NMR is growing steadily, thanks to the increasing power of ultra-high-field superconducting magnets and cryogenic probes, in return for very high purchase and operating costs. In recent years, the arrival of new generations of transportable, cryofluid-free spectrometers promises interesting alternatives [1]. However, at lower fields, spectra lack sensitivity and spectral resolution. To overcome these limitations, we have recently implemented advanced techniques on a 1 T instrument equipped with a gradient coil: solvent peak suppression [2], DOSY [3], homonuclear decoupling [4] and ultra-fast 2D methods [5]. The main applications of these techniques will be presented, such as reaction monitoring, authentication and control of cellular bioprocesses.

[1] B. Blümich, J. Magn. Reson. 2019, 306, 27-35.

[2] B. Gouilleux et al., Magn. Reson. Chem. 2017, 55, 91–98.

[3] G. Assemat et al., J. Pharm. Biomed. Anal. 2018, 160, 268–275.

[4] T. Castaing-Cordier et al., ChemPhysChem., 2019, 20, 736-744.

[5] B. Gouilleux et al., Analyst 2015, 140, 7854–7858.

We look forward to your attendance and participation,

Xavier Trivelli for IR-RMN THC, Lille site